Dental Adhesives- which one, when, how and why?
Dental Adhesives- which one, when, how and why?

Table of Contents


Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age with reproductive, metabolic and endocrine implications. While the exact pathophysiological mechanisms of the syndrome are unknown, its heterogeneity suggests a multifactorial causal background. In the last two decades, numerous environmental chemicals, including Bisphenol-A (BPA) that is used in the synthesis of polycarbonate plastics, have been proposed as potential contributors to the aetiology of PCOS. This review provides a holistic overview of the available data regarding the possible relation of PCOS with BPA exposure. We have included a total number of 24 studies. Eleven human case-control and 13 animal studies provided data regarding this potential relation. Accumulating evidence suggests that a correlation between high levels of BPA and the presence of PCOS may exist. Contradicting results from human and animal studies, however, render it difficult to conclude on the exact role of BPA in the pathogenesis of PCOS. BPA may constitute a consequence of the syndrome rather than a cause, but further research is still needed to clarify this. Continued efforts to study the early origins of PCOS, using prospective-designed studies, are required to identify the exact effect of BPA on women with PCOS.

  1. Research funding: None declared.

  2. Author contributions: All authors contributed to the design and implementation of the research, literature search, data collection, discussion of the findings and to the writing of the manuscript.

  3. Competing interests: The authors declare no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


1. March, WA, Moore, VM, Willson, KJ, Phillips, DIW, Norman, RJ, Davies, MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod 2010;25:544–51. in Google Scholar PubMed

2. Dumesic, DA, Oberfield, SE, Stener-Victorin, E, Marshall, JC, Laven, JS, Legro, RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev 2015;36:487–25. in Google Scholar PubMed PubMed Central

3. Trikudanathan, S. Polycystic ovarian syndrome. Med Clin North Am 2015;99:221–35. in Google Scholar PubMed

4. Moran, LJ, Norman, RJ, Teede, HJ. Metabolic risk in PCOS: phenotype and adiposity impact. Trends Endocrinol Metabol 2015;26:136–43. in Google Scholar PubMed

5. Diamanti-Kandarakis, E, Dunaif, A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine Rev 2012;33:981–30. in Google Scholar PubMed PubMed Central

6. Ajmal, N, Khan, SZ, Shaikh, R. Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article. Eur J Obstet Gynecol Reprod Biol 2019:100060. in Google Scholar PubMed PubMed Central

7. Dumesic, DA, Oberfield, SE, Stener-Victorin, E, Marshall, JC, Laven, JS, Legro, RS, et al. Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. Endocrine Rev 2015;36:487–525. in Google Scholar

8. Condorelli, RA, Calogero, AE, Di Mauro, M, Mongioi’, LM, Cannarella, R, Rosta, G, et al. Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index. J Endocrinol Invest 2018;41:383–8. in Google Scholar PubMed

9. Diamanti-Kandarakis, E, Christakou, C, Marinakis, E. Phenotypes and enviromental factors: their influence in PCOS. Curr Pharmaceut Des 2012;18:270–82. in Google Scholar PubMed

10. Wijeyaratne, CN, Seneviratne, RDA, Dahanayake, S, Kumarapeli, V, Palipane, E, Kuruppu, N, et al. Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic. Human Reprod 2010;26:202–13. in Google Scholar PubMed

11. Azziz, R, Carmina, E, Dewailly, D, Diamanti-Kandarakis, E, Escobar-Morreale, HF, Futterweit, W, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 2009;91:456–88. in Google Scholar PubMed

12. Rutkowska, A, Rachoń, D. Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS). Gynecol Endocrinol 2014;30:260–5. in Google Scholar PubMed

13. Dorothea, G, Fiege, H, Voges, H-W, Hamamoto, T, Umemura, S, Iwata, T, et al. Phenol Derivatives, Ullmann’s Encyclopedia of Industrial Chemistry; 1991, Barbara, E.Suche in Google Scholar

14. Bolli, A, Bulzomi, P, Galluzzo, P, Acconcia, F, Marino, M Bisphenol A impairs estradiol‐induced protective effects against DLD‐1 colon cancer cell growth. IUBMB life 2010;62:684–7. in Google Scholar PubMed

15. Geens, T, Goeyens, L, Covaci, A. Are potential sources for human exposure to bisphenol-A overlooked? Intern J Hygiene Environ Health 2011;214:339–47. in Google Scholar PubMed

16. Donatella, C, Segni, ND, Mallozzi, M, Giovanale, V, Mantovani, A, Marci, R, et al. Bisphenol a and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies; 2014.Suche in Google Scholar

17. Diamanti-Kandarakis, E, Bourguignon, J-P, Giudice, LC, Hauser, R, Prins, GS, Soto, AM, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocrine Rev 2009;30:293–42. in Google Scholar PubMed PubMed Central

18. Acconcia, F, Pallottini, V, Marino, M. Molecular mechanisms of action of BPA. Dose-Resp 2015;13:1559325815610582.10.1177/1559325815610582Suche in Google Scholar PubMed PubMed Central

19. Kechagias, K, Anastasaki, P, Kyriakidou, M, Dedi, KD Bisphenol A in Dentistry. Eur J Prosthodont Restor Dent 2020. in Google Scholar PubMed

20. Koch, HM, Calafat, AM. Human body burdens of chemicals used in plastic manufacture. Philosop Trans Royal Soci B: Biolog Sci 2009;364:2063–78. in Google Scholar PubMed PubMed Central

21. Geens, T, Aerts, D, Berthot, C, Bourguignon, J, Goeyens, L, Lecomte, P, et al. A review of dietary and non-dietary exposure to bisphenol-A. Food and Chem Toxicol 2012;50:3725–740.10.1016/j.fct.2012.07.059Suche in Google Scholar PubMed

22. Calafat, AM, Ye, X, Wong, L-Y, Reidy, JA, Needham, LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 2008;116:39–44. in Google Scholar PubMed PubMed Central

23. Schug, TT, Janesick, A, Blumberg, B, Heindel, JJ. Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Bio 2011;127:204–15. in Google Scholar PubMed PubMed Central

24. Gascon, M, Casas, M, Morales, E, Valvi, D, Ballesteros-Gómez, A, Luque, N, et al. Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. J Allergy and Clin Immu 2015;135:370–8.e7. in Google Scholar PubMed

25. Spanier, AJ, Kahn, RS, Kunselman, AR, Schaefer, EW, Hornung, R, Xu, Y, et al. Bisphenol A exposure and the development of wheeze and lung function in children through age 5 years. JAMA Pedia 2014;168:1131–7. in Google Scholar PubMed PubMed Central

26. Rochester, JR. Bisphenol A and human health: a review of the literature. Reproductive Toxicol 2013;42:132–55. in Google Scholar PubMed

27. Peretz, J, Vrooman, L, Ricke, WA, Hunt, PA, Ehrlich, S, Hauser, R, et al. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 2014;122:775–86.10.1289/ehp.1307728Suche in Google Scholar PubMed PubMed Central

28. Tomza-Marciniak, A, Stępkowska, P, Kuba, J, Pilarczyk, B. Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies. J Appl Toxicol 2018;38:51–80. in Google Scholar PubMed

29. Caserta, D, Di Segni, N, Mallozzi, M, Giovanale, V, Mantovani, A, Marci, R, et al. Bisphenol A and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies. Reprod Biol Endocrinol 2014;12:37. in Google Scholar PubMed PubMed Central

30. Barrett, ES, Sobolewski, M. Polycystic ovary syndrome: do endocrine-disrupting chemicals play a role? in Seminars in reproductive medicine. Thieme Medical Publishers; 2014.10.1055/s-0034-1371088Suche in Google Scholar PubMed PubMed Central

31. Padmanabhan, V, Sarma, HN, Savabieasfahani, M, Steckler, TL, Veiga-Lopez, A. Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators. Intern J Androl 2010;33:394–404. in Google Scholar PubMed PubMed Central

32. Bolli, A, Galluzzo, P, Ascenzi, P, Del Pozzo, G, Manco, I, Vietri, MT, et al. Laccase treatment impairs bisphenol A‐induced cancer cell proliferation affecting estrogen receptor α‐dependent rapid signals. IUBMB Life 2008;60:843–52.10.1002/iub.130Suche in Google Scholar PubMed

33. Welshons, WV, Nagel, SC, vom Saal, FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006;147:s56–9. in Google Scholar

34. Wetherill, YB, Akingbemi, BT, Kanno, J, McLachlan, JA, Nadal, A, Sonnenschein, C, et al. In vitro molecular mechanisms of bisphenol A action. Reprod Toxicol 2007;24:178–98. in Google Scholar

35. Matsushima, A, Kakuta, Y, Teramoto, T, Koshiba, T, Liu, X, Okada, H, et al. Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ. J Biochem 2007;142:517–24. in Google Scholar

36. Acconcia, F, Pallottini, V, Marino, M. Molecular Mechanisms of Action of BPA. Dose Resp 2015;13:1559325815610582.10.1177/1559325815610582Suche in Google Scholar

37. Hamilton, KJ, Hewitt, SC, Arao, Y, Korach, KS Estrogen hormone biology, in Current topics in developmental biology. Elsevier; 2017: pp. 109–46.10.1016/bs.ctdb.2016.12.005Suche in Google Scholar

38. Ikezuki, Y, Tsutsumi, O, Takai, Y, Kamei, Y, Taketani, Y. Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Human Reprod 2002;17:2839–41. in Google Scholar

39. Zhou, W, Fang, F, Zhu, W, Chen, Z-J, Du, Y, Zhang, J. Bisphenol A and ovarian reserve among infertile women with polycystic ovarian syndrome. Intern J Environ Res Pub Health 2017;14:18.10.3390/ijerph14010018Suche in Google Scholar

40. Zhou, W, Liu, J, Liao, L, Han, S, Liu, J. Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells. Mol Cell Endocrinol 2008;283:12–8. in Google Scholar

41. Rosenfield, RL, Barnes, RB, Cara, JF, Lucky, AW. Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome. Fertil Sterility 1990;53:785–91. in Google Scholar

42. Mlynarčíková, A, Kolena, J, Ficková, M, Scsuková, S. Alterations in steroid hormone production by porcine ovarian granulosa cells caused by bisphenol A and bisphenol A dimethacrylate. Mol Cell Endocrinol 2005;244:57–62.10.1016/j.mce.2005.02.009Suche in Google Scholar PubMed

43. Lischinsky, A, Armstrong, DT. Granulosa cell stimulation of thecal androgen synthesis. Canad J Phy Pharmacol 1983;61:472–7. in Google Scholar

44. Wachs, DS, Coffler, MS, Malcom, PJ, Shimasaki, S, Chang, RJ. Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome. J Clini Endocrinol Metabolism 2008;93:1827–33. in Google Scholar

45. Wang, Y, Zhu, Q, Dang, X, He, Y, Li, X, Sun, Y. Local effect of bisphenol A on the estradiol synthesis of ovarian granulosa cells from PCOS. Gynecol Endocrinol 2017;33:21–5. in Google Scholar

46. Déchaud, H, Ravard, C, Claustrat, F, de la Perrière, AB, Pugeat, M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG) 1. Steroids 1999;64:328–34. in Google Scholar

47. Masuno, H, Iwanami, J, Kidani, T, Sakayama, K, Honda, K. Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway. Toxicolog Sci 2005;84:319–27. in Google Scholar PubMed

48. Hugo, ER, Brandebourg, TD, Woo, JG, Loftus, J, Alexander, JW, Ben-Jonathan, N. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environml Health Perspect 2008;116:1642–7. in Google Scholar PubMed PubMed Central

49. Phrakonkham, P, Viengchareun, S, Belloir, C, Lombès, M, Artur, Y, Canivenc-Lavier, M-C. Dietary xenoestrogens differentially impair 3T3-L1 preadipocyte differentiation and persistently affect leptin synthesis. J Steroid Biochem Mol Biol 2008;110:95–103. in Google Scholar PubMed

50. Wang, J, Sun, B, Hou, M, Pan, X, Li, X. The environmental obesogen bisphenol A promotes adipogenesis by increasing the amount of 11β-hydroxysteroid dehydrogenase type 1 in the adipose tissue of children. Intern J Obesity 2013;37:999. in Google Scholar PubMed

51. Nadal, A, Alonso-Magdalena, P, Soriano, S, Quesada, I, Ropero, AB. The pancreatic β-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes. Mol Cell Endocrinol 2009;304:63–8. in Google Scholar PubMed

52. Alonso-Magdalena, P, Ropero, AB, Carrera, MP, Cederroth, CR, Baquié, M, Gauthier, BR, et al. Pancreatic insulin content regulation by the estrogen receptor ERα. PloS one 2008;3:e2069. in Google Scholar PubMed PubMed Central

53. Puttabyatappa, M, Martin, JD, Andriessen, V, Stevenson, M, Zeng, L, Pennathur, S, et al. Developmental programming: Changes in mediators of insulin sensitivity in prenatal bisphenol A-treated female sheep. Reprod Toxicol 2019;85:110–22. in Google Scholar

54. Kundakovic, M, Champagne, FA. Epigenetic perspective on the developmental effects of bisphenol A. Brain Behav Immun 2011;25:1084–93. in Google Scholar

55. Ho, S-M, Tang, W-Y, Belmonte de Frausto, J, Prins, GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 2006;66:5624–32. in Google Scholar

56. Gore, AC. Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems. Front Neuroendocrinol 2008;29:358–74. in Google Scholar

57. Chiam, K, Tilley, WD, Butler, LM, Bianco-Miotto, T. The dynamic and static modification of the epigenome by hormones: a role in the developmental origin of hormone related cancers. Biochim Biophys Acta 2009;1795:104–9. in Google Scholar

58. Palioura, E, Diamanti-Kandarakis, E. Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs). Rev Endocr Metab Disord 2015;16:365–71. in Google Scholar

59. Gapp, K, Bohacek, J. Epigenetic germline inheritance in mammals: looking to the past to understand the future 2018;17:e12407. in Google Scholar

60. Markey, CM, Coombs, MA, Sonnenschein, C, Soto, AM. Mammalian development in a changing environment: exposure to endocrine disruptors reveals the developmental plasticity of steroid-hormone target organs. Evol Dev 2003;5;67–75. in Google Scholar

61. Rubin, BS, Murray, MK, Damassa, DA, King, JC, Soto, AM. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect 2001;109;675–80. in Google Scholar

62. Kato, H, Ota, T, Furuhashi, T, Ohta, Y, Iguchi, T. Changes in reproductive organs of female rats treated with bisphenol A during the neonatal period. Reprod Toxicol 2003;17:283–8. in Google Scholar

63. Adewale, HB, Jefferson, WN, Newbold, RR, Patisaul, HB. Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons. Biol Reprod 2009;81:690–9. in Google Scholar

64. Fernández, M, Bourguignon, N, Lux-Lantos, V, Libertun, C. Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats. Environ Health Perspect 2010;118:1217–22. in Google Scholar

65. Goodarzi, MO, Dumesic, DA, Chazenbalk, G, Azziz, R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nature Rev Endocrinol 2011;7:219. in Google Scholar

66. Newbold, RR, Jefferson, WN, Padilla-Banks, E. Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol 2007;24:253–8. in Google Scholar

67. Calhoun, KC, Padilla-Banks, E, Jefferson, WN, Liu, L, Gerrish, KE, Young, SL, et al. Bisphenol A exposure alters developmental gene expression in the fetal rhesus macaque uterus. PloS one 2014;9. in Google Scholar

68. Veiga-Lopez, A, Beckett, EM, Abi Salloum, B, Ye, W, Padmanabhan, V. Developmental programming: prenatal BPA treatment disrupts timing of LH surge and ovarian follicular wave dynamics in adult sheep. Toxicol Appl Pharmacol 2014;279:119–28. in Google Scholar

69. Veiga-Lopez, A, Luense, LJ, Christenson, LK, Padmanabhan, V. Developmental programming: gestational bisphenol-A treatment alters trajectory of fetal ovarian gene expression. Endocrinology 2013;154:1873–84. in Google Scholar

70. Patisaul, HB, Mabrey, N, Adewale, HB, Sullivan, AW. Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats. Reprod Toxicol 2014;49:209–18. in Google Scholar

71. Newbold, RR, Jefferson, WN, Padilla-Banks, E. Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environ Health Persp 2009;117:879–85. in Google Scholar

72. Honma, S, Suzuki, A, Buchanan, DL, Katsu, Y, Watanabe, H, et al. Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 2002;16:117–22. in Google Scholar

73. Howdeshell, K., Hotchkiss, AK, Thayer, KA, Vandenbergh, JG, vom Saal, FS. Environmental toxins: exposure to bisphenol A advances puberty. Nature 1999;401:763. in Google Scholar

74. Suzuki, A, Sugihara, A, Uchida, K, Sato, T, Ohta, Y, Katsu, Y, et al. Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice. Reprod Toxicol 2002;16:107–16. in Google Scholar

75. YOKOTA, H, Iwano, H, Endo, M, Kobayashi, T, Inoue, H, Ikushiro, S-I, et al. Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. Biochem J 1999;340:405–9. in Google Scholar

76. Robl, J, Thomford, PJ, Wu, MC, Dziuk, PJ. Effect of estrogen, testosterone, and phenobarbital on uterine weight and liver microsomal enzymes in prepuberal mice. Pediatric Pharmacology (New York, NY) 1985;5:157–64.Suche in Google Scholar

77. Kandaraki, E, Chatzigeorgiou, A, Livadas, S, Palioura, E, Economou, F, Koutsilieris, M, et al. Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab 2011;96:E480–4. in Google Scholar PubMed

78. Akin, L, Kendirci, M, Narin, F, Kurtoglu, S, Saraymen, R, Kondolot, M, et al. The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Acta Paediatr 2015;104:e171–7.10.1111/apa.12885Suche in Google Scholar PubMed

79. Konieczna, A, Rachoń, D, Owczarek, K, Kubica, P, Kowalewska, A, Kudłak, B, et al. Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome. Reprod Toxicol 2018;82:32–7. in Google Scholar PubMed

80. Hossein Rashidi, B, Amanlou, M, Behrouzi Lak, T, Ghazizadeh, M, Haghollahi, F, Bagheri, M, et al. The Association Between Bisphenol A and Polycystic Ovarian Syndrome: A Case-Control Study. Acta Med Iran 2017;55:759–64.Suche in Google Scholar

81. Vagi, SJ, Azziz-Baumgartner, E, Sjödin, A, Calafat, MA, Dumesic, D, Gonzalez, L, et al. Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: a case-control study. BMC Endocr Disord 2014;14:86. in Google Scholar PubMed PubMed Central

82. Tarantino, G, Valentino, R, Somma, CD, D’Esposito, V, Passaretti, F, Pizza, G, et al. Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis. Clin Endocrinol (Oxf) 2013;78:447–53. in Google Scholar PubMed

83. Ho, C-H, Chang, C-M, Li, H-Y, Shen, H-Y, Lieu, F-K, Wang, PS-G. Dysregulated immunological and metabolic functions discovered by a polygenic integrative analysis for PCOS. Reproductive BioMedicine Online 2020;40:160–7. in Google Scholar PubMed

84. Takeuchi, T, Tsutsumi, O. Serum bisphenol a concentrations showed gender differences, possibly linked to androgen levels. Biochem Biophys Res Commun 2002;291:76–8. in Google Scholar PubMed

85. Takeuchi, T, Tsutsumi, O, Ikezuki, Y, Takai, Y, Taketani, Y. Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction. Endocr J 2004;51:165–9. in Google Scholar PubMed

86. Barber, TM, McCarthy, MI, Wass, JAH, Franks, S. Obesity and polycystic ovary syndrome. Clinical Endocrinol 2006;65:137–45. in Google Scholar PubMed

87. Fernández, M, Bourguignon, N, Lux-Lantos, V, Libertun, C. Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats. Environ Health Persp 2010;118:1217–22. in Google Scholar PubMed PubMed Central

88. Tsutsumi, O. Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproduction. J Steroid Biochem Mol Biol 2005;93:325–30. in Google Scholar PubMed

89. Takeuchi, T, Tsutsumi, O, Ikezuki, Y, Kamei, Y, Osuga, Y, Fujiwara, T, et al. Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity. Endocr J 2006;53:485–91. in Google Scholar PubMed

90. Yokota, H, Iwano, H, Endo, M, Kobayashi, T, Inoue, H, Ikushiro, S-I, et al. Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. Biochem J 1999;340:405–9. in Google Scholar

91. Hu, Y, Wen, S, Yuan, D, Peng, L, Zeng, R, Yang, Z, et al. The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: a systematic review and meta-analysis. Gynecol Endocrinol 2018;34:370–7. in Google Scholar PubMed

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